Active Research Funding

R01AG072681 (Zeki Al Hazzouri/ Glymour): Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimers Disease and Related Disorders

Major Goals: This study will combine eight data sources on lifecourse social and vascular risk factors for Alzheimer’s Disease and Related Dementias (ADRD) to create a large (N=304,171) and diverse (25% Black) synthetic birth cohort (age 0 to 90) for research on ADRD. We will apply rigorous methods to estimate and incorporate corrections for selection forces, including survival, enrollment, attrition, and reverse causation from incipient dementia to risk factor changes. The synthetic cohort will then be used to rigorously estimate how lifecourse social and vascular factors and hypothetical age-specific interventions on those risk factors would affect ADRD risk and ADRD disparities. Project Number: R01AG072681 Name of PD/PI: Zeki Al Hazzouri Source of Support: NIA Primary Place of Performance: Columbia University Project/Proposal Start and End Dates: 04/2021 – 03/2026

https://reporter.nih.gov/project-details/10985783

R01AG074076 (Zeki Al Hazzouri / Elbejjani / Sibai): Late Life Learning, Dementia, and Overall Health: An investigation of the University for Seniors in Beirut

Major Goals: This project will capitalize on an ongoing and well-established late life learning (LLL) program, the University for Seniors (UfS), in Beirut, Lebanon. We will build a prospective cohort and we will include two waves of data collection to rigorously evaluate the relationships of LLL with cognitive function, Alzheimer’s Disease and Related Dementias (ADRD), and other related outcomes in older age, whether these relationships are mediated by educational and social engagement, and whether LLL would modify the influence of earlier and lifecourse psychosocial exposures. Through a detailed capacity building program, this application will build research and infrastructure capacities to delineate opportunities for dementia prevention in Lebanon and other low-resourced settings Project Number: R01AG074076-01A1 Name of PD/PI: Adina Zeki Al Hazzouri Source of Support: NIA Primary Place of Performance: Columbia University, New York, NY Project Start and End Dates: 07/01/22 - 06/30/27

https://reporter.nih.gov/search/3WyVNAjlUk2CvEK4QiiRjQ/project-details/10845557

R01AG081973 (Zeki Al Hazzouri / Calonico / Odden): Illuminating our understanding of statins and Alzheimer’s Disease and Dementia using modern causal inference methods

Major Goals: The goal of this grant is to use electronic health record data to create a large and diverse sample for evaluating the relationship between statin medications and Alzehimer’s disease and Alzheimer’s related dementias (ADRD) risk using a quasi-experimental approach and machine learning methods.

https://reporter.nih.gov/project-details/10807402

R01AG089174 (Zeki Al Hazzouri/Glymour) : A Multilevel Investigation of Migration and Dementia Risk Among Mexican Americans

Major Goals: Using a pooled binational life course dataset with harmonized cognitive outcomes (HCAP) and built-in longitudinal propensity scores of healthy in-migration and unhealthy out-migration, we will estimate the association of migration and ADRD risk, assess how different immigration policy climates and social contexts modify the effects of migration on dementia risk, and examine underlying biosocial pathways. Source of Support: NIA Status: PENDING NOA Project start and End dates: 07/01/2024-06/30/2029

https://reporter.nih.gov/project-details/10979824

R01AG085481 (Yaffe/Zeki Al Hazzouri/Calonico): Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US Veterans

Major Goals: The present study will use data from the Veteran Health Administration (VHA), which is an integrated nationwide healthcare system, to examine the relationships between hypertension, blood pressure targets, and ADRD risk in a large, national, and increasingly diverse population of US veterans. We will estimate the association of hypertension and ADRD risk, assess how military-related exposures influence this relationship, and estimate hypertension treatment effects at various treatment targets for optimized reduction in ADRD burden. Project Number: R01AG085481 Source of Support: NIA Status: PENDING (score: 20th percentile) Project Start and End Dates: 11/01/2024-10/30/2029

R01AG087158-01 (Aiello / Belsky / Handa)

Major Goals: The primary objectives of this project are to assess the effects of a cash transfer program on the slowing of biological aging and reduction of dementia risk in younger and older individuals. Additionally, we aim to quantify associations between biological aging and cognitive function in this population. Results of this research could have substantial impact for public health by revealing causal, long-term consequences of economic interventions for health and cognitive aging. Moreover, it will generate new knowledge about biological aging and Alzheimer’s Disease risk in low resource settings.

Pending Research Funding

R01AG088005 (Zhang) Engaging Aging Minds: Labor Force Participation, Stimulating Activities, and Cognitive Aging Across Diverse International Settings

Major Goals: This research will leverage cross-nationally harmonized data from three low- and middle-income countries (China, India, and Mexico) and two high-income countries (The US and England) to understand the impact of labor force participation and stimulating activities on cognitive aging processes by gender and across sociocultural contexts.

R01AG08809 (Arce) Mild Cognitive Impairment and Alzheimer’s Disease and Related Dementias: Cross- national longitudinal prognosis and risk factors

Major Goals: The overall goal of this study is to improve cross-national measurement of MCI and to characterize its longitudinal course across populations with varied social, economic, cultural, and healthcare life experiences.

Past Research Funding

RF1AG054443 (Yaffe/ Zeki Al Hazzouri): Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment

Major Goals: The goal of this study isto investigate cardiovascular risk factors over the life-course and their association withdementia risk. Project Number: RF1AG054443 Name of PD/PI: Yaffe; Role: MPI Source of Support: NIA Primary Place of Performance: University of California, San Francisco Project/Proposal Start and End Dates: 05/01/17 – 08/31/22

RF1AG055486 (Zeki Al Hazzouri/ Glymour): A Binational Study to Understand Dementia Risk and Disparities of Mexican Americans: The Role of Migration and Social Determinants.

Major Goals: The goal of this study is to create a binational study of two nationally representative cohorts from the US andMexico to study how migration influences dementia risk of Mexican Americans and factors that increase or reduce dementia risk in Mexican Americans. STATUS OF SUPPORT: ACTIVE Project Number: RF1AG055486 Name of PD/PI: Zeki Al Hazzouri Source of Support: NIA Primary Place of Performance: University of California, San Francisco Project/Proposal Start and End Dates: 06/1517 – 08/31/22

1R56 AG061177-01A1 (Zeki Al Hazzouri/Odden): Statins and Risk of Alzheimer's Disease and Related Dementias: A Novel Quasi- Experimental Approach to Identify Causal Effects.

Major Goals: The goal of this grant is to create a quasi-experiment using a clinical guideline in the UK and established statistical methods in economics, regression discontinuity, to study the effect of statin on dementia risk overall, and across relevant subgroups. Status of Support: COMPLETED Project Number: R56AG061177 Name of PD/PI: Zeki Al Hazzouri Source of Support: NIH: National Institute of Aging Primary Place of Performance: Columbia University Project/Proposal Start and End Dates: 08/15/2019 – 07/31/21

K01AG047273 (Zeki Al Hazzouri): Lifecourse cardiovascular risk, depression and cognition in Black and white adults.

Major Goals: The goal of this grant is to examine the associations of cardiovascular risk factors with cognitive function and depressive symptoms, and the role of structural brain changes. Status of Support: COMPLETED Project Number: K01AG047273 Name of PD/PI: Zeki Al Hazzouri Source of Support: NIH: National Institute of Aging Primary Place of Performance: University of California San Francisco; University of Miami Project/Proposal Start and End Dates: 04/2014 – 03/19 Total Award Amount:

Association Between Depression and Risk of Alzheimer’s Disease Across the Lifespan. Project Number: N/A Name of PD/PI: Yaffe; Role: MPI. Source of Support: Alzheimer’s Drug Discovery Foundation

Major Goals: The goal of this study is to understand the relationship between depressive symptoms and Alzheimer’s disease in order to inform prevention and treatment strategies and improve the public health burden for both conditions. Primary Place of Performance: Columbia University Project/Proposal Start and End Dates: 06/2018 – 05/2020

Familial hypercholesterolemia screening in children: population impact of phenotype, genotype, and cascade approaches. Project Number: R01HL141823 Name of PD/PI: Moran/Ferranti. Role: Co-Investigator Source of Support: NHLBI

Major Goals: The goal of this study is to combine traditional epidemiology with a more public health viewpoint, addressing the question of whether there is a value to screening for genetic disorders in the general population, even relatively common genetic disorders. This goal will be accomplished using machine learning methods and cost benefit analysis.